On January 1, 2015, WXIN became the second largest Fox affiliate (behind WRAZ in Raleigh, North Carolina) owned in a duopoly with a "Big Three" station when WTTV switched from The CW to CBS; it is also the only station in Indianapolis to have never changed its network affiliation.
On May 8, 2017, Sinclair Broadcast Group announced that it would acquire Tribune Media for .9 billion, plus the assumption of .7 billion in debt held by Tribune.
The station originally operated from studio facilities located on North Meridian Street in Indianapolis' Television Row section.
The two stations share studio facilities located on Network Place (near 71st Street & I-465) at the Intech Park office development in northwestern Indianapolis; WXIN maintains transmitter facilities located on West 73rd Street (or Westlane Road) on the northern outskirts of the city (west of Meridian Hills).
On cable, WXIN is available in standard definition on Comcast Xfinity, Charter Spectrum and AT&T U-verse channel 11, in high definition on Spectrum and AT&T U-verse channel 1011 and Xfinity channel 1059.
In 2011, WXIN and WSJV in South Bend became the only full-power Fox affiliates in Indiana to carry the network's programming on their primary channels, after Fox programming was relegated to digital subchannels of Big Three-affiliated stations in three markets due to a dispute between the network and the Nexstar Broadcasting Group over reverse compensation of retransmission consent fees that led to Nexstar's Evansville and Fort Wayne stations (WTVW and WFFT-TV) being stripped of their Fox affiliations, (WFFT-TV rejoined Fox on March 1, 2013, after Nexstar settled a 2011 lawsuit against Granite Broadcasting citing undue control of five major network affiliations on Granite's virtual duopoly in Fort Wayne at the time – ABC and The CW on WPTA and NBC, Fox and My Network TV on WISE-TV).
As a result of fellow charter affiliate WFFT-TV losing its Fox affiliation, WXIN became the longest-tenured Fox affiliate in the state of Indiana.