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    Although the cause of multiple sclerosis (MS) is unknown, epidemiologic studies support both genetic and environmental components of susceptibility.

    Reports of clusters, small “epidemics,” geographic variation in prevalence, and alteration of MS susceptibility by migration support an environmental factor (or factors).

    Currently, there is little evidence for a single or unique environmental cause of MS.

    LOS ANGELES (Reuters) - California will launch the world's largest regulated commercial market for recreational marijuana on Monday, as dozens of newly licensed stores catering to adults who enjoy the drug for its psychoactive effects open for business up and down the state. Colorado, Washington, Oregon, Alaska and Nevada were the first to introduce recreational pot sales on a state-regulated, licensed and taxed basis.

    When overexcited by drugs, the reward system creates feelings of euphoria.

    This is also why some studies have suggested that excessive use can be a problem in some people: The more often you trigger that euphoria, the less you may feel for other rewarding experiences.

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    A preliminary 2005 study of 58 patients with RA, roughly half of whom were given a placebo and roughly half of whom were given a cannabis-based medicine called Sativex, found "statistically significant improvements in pain on movement, pain at rest ... Other studies testing both other cannabinoid products and inhaled marijuana have shown similar pain relieving effects, according to the report.

    The first study showed a decrease in symptoms in 10 of 11 subjects on cannabis, compared with just four of 10 on the placebo.

    But when they did a follow-up study using low-dose cannabidiol they saw no effect in the patients.

    REUTERS/Dominick Reuter And it can distort your sense of time Feeling as if time is sped up or slowed down is one of the most commonly reported effects of using marijuana.

    A 2012 paper sought to draw some more solid conclusions from some of the studies on those anecdotal reports, but it was unable to do so.

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