Vanity Fair invited Mc Adams, along with actresses Scarlett Johansson and Keira Knightley, to appear on its March 2006 cover, the annual Hollywood issue.
Upon arrival on the photo set, Mc Adams discovered it was a nude session, declined and left.
Afterwards, Mc Adams starred with Tim Robbins and Michael Peña in the road trip comedy-drama The Lucky Ones, a story about three Iraq War soldiers on a brief road trip back in the United States.Tina Fey, who co‑starred in the film and wrote the screenplay, has credited Mc Adams with teaching her how to act in front of a camera rather than an audience: "She's a film actor. And so I kind of learned that lesson from watching her." Later in 2004, Mc Adams starred opposite fellow Canadian Ryan Gosling in the romantic drama The Notebook, based on Nicholas Sparks' novel of the same name.She played Allie Hamilton, a wealthy southern belle who has a forbidden love affair with Gosling's poor labourer, Noah Calhoun.In 2010, Mc Adams appeared in her first star vehicle, the comedy Morning Glory.In 2015, her highest profile roles were in the second season of the HBO crime drama True Detective, and as journalist Sacha Pfeiffer in the drama Spotlight.