That same year, Lowe filmed Stir of Echoes: The Homecoming, the sequel to the 1999 Kevin Bacon thriller Stir of Echoes.In 2006, it was announced that Lowe would join the cast of Brothers & Sisters for a guest run of several episodes.In January 2007, ABC announced that Lowe would be staying on Brothers and Sisters as a "special guest star" for the rest of Season 1 after Lowe's initial appearance on the show in November 2006 brought the best ratings and demographic showing for the show since its premiere.Soon after ABC announced an early Season 2 renewal for Brother & Sisters in March 2007, Lowe announced he would be returning for the show's second season., Anthony Scaramucci's wife Deidre Ball actually filed for divorce on July 6, while she was still pregnant with the couple's second child together.
Eventually, Lowe left the series, not long before Sorkin and director/executive producer Thomas Schlamme unceremoniously quit over a dispute with NBC.
He also appeared on The Tonight Show with Conan O'Brien.
Lowe is currently teaming up with 44 Blue to produce a reality series entitled Potomac Fever about young adults living in Washington, D. In 2011, Lowe guest starred in a recurring role on Showtime's comedy Californication.
He continued to appear in the series until the end of the 2009–10 season.
Unhappy with the stories and his lack of screen time in the fourth season, Lowe announced he would leave.